Can I take Berberine and L-carnitine Together: Understanding its Benefits and Side Effects


In the search to attain wellness, many people try different dietary supplements, Berberine and L-carnitine are among those. This blog will examine their role individually and how they help to manage high blood sugar. The most intriguing question that may determine the effectiveness of these supplements when taken together. However, we recommend consulting a healthcare professional before determining: “Can I take Berberine and L-carnitine Together.”

Berberine can be extracted from a plant, and it is quite effective in managing high blood sugar and helping you attain wellness. L-carnitine is a protein that makes you feel energetic while doing intensive exercises, which means it helps in proper energy distribution when required. We will explore the idea of taking them both more. Additionally, this article will discuss.

  • Berberine and its use
  • L-carnitine and its use
  • Role of both in managing high blood sugar
  • Individual and combined side effects

What is Berberine and Its Use

What is Berberine and Its Use
What is Berberine and Its Use

Berberine is a natural compound found in many plants, including barberry and Oregon grape. The extract has been used to treat various ailments and was quite popularly practiced in Ayurveda and Chinese traditions. It has again gained some limelight as there is a linkage between high blood sugar control and Berberine.

1. Properties

Berberine has some notable properties that can contribute to its therapeutic use. Some of them are:

A. Antioxidant and Anti-Inflammatory

  • Berberine has antioxidant properties, which means it can neutralize free radicals and eliminate the threat caused by oxidative stress generated by them. These properties protect against various chronic disorders, such as high blood sugar or high blood pressure.
  • It can reduce body inflammation by inhibiting inflammatory pathways and cytokines. 

B Antimicrobial and Hypoglycemic

  • Berberine is often considered to inhibit the growth of several pathogens like bacteria, fungi, and viruses. 
  • The hypoglycemic effect makes Berberine beneficial for those who have diabetes or insulin resistance.
  • Improving insulin sensitivity promotes glucose uptake into cells. Berberine also inhibits glucose production in the liver, which has proved effective in controlling diabetes.

C. Neuroprotective and Hypolipidemic

  • Berberine possesses neuroprotective properties, which means it safeguards nerve cells from damage and degeneration. This particular benefit can be beneficial for Alzheimer’s and Parkinson’s diseases.
  • Berberine can lower the levels of cholesterol by reducing its production in the liver and also clearing bloodstreams with cholesterol deposition. This can help treat various cardiac complications.

2. Health Benefits

Consumption of Berberine is often associated with many health benefits, and some of them are:

  • Cholesterol management
  • Weight Management
  • Improving gut health
  • Anti-inflammatory and antioxidant
  • Antimicrobial
  • Improve cardiac health

3. Side Effects

Berberine consumption is generally considered safe for humans. However, some of the known side effects are.

  • Gastrointestinal discomfort can include bloating, gas, constipation, and diarrhea.
  • It can lower blood pressure, which can cause dizziness, lightheadedness, or fainting. People who are already taking blood pressure medicine are more prone to this side effect.
  • Allergic reactions are common among sensitive and allergic people. Symptoms like itching or skin rash show a possible allergy.
  • When there is a history of prolonged and high dosage use of Berberine, liver toxicity comes under the probability.

Also Read: Can You Take Berberine and Magnesium Together

What is L-carnitine and Its Use

What is L-carnitine and Its Use
What is L-carnitine and Its Use
  • L-carnitine is a naturally occurring compound that plays an important role in energy metabolism. It is involved in transporting fatty acids into mitochondria.
  • It is also involved in regulating cellular metabolism and removing waste products from cells.

1. Properties

L-carnitine processes several properties which can influence our well-being. Some of them are. 

A. Energy Production and Fat Metabolism

  • It is involved in fatty cell transport into mitochondria. L-carnitine can generate adenosine triphosphate (ATP), which is also known as the primary energy currency of the body.
  • With this property, L-carnitine can support overall energy production and metabolism.
  • L-carnitine is concentrated in skeletal muscles from there, it can help produce energy metabolism during exercises. 
  • It supports fat metabolism by getting involved in energy production. This can be done as it plays a crucial role in transporting the fatty acid into mitochondria, where it is oxidized to produce energy.

B. Brain and Cardiac Health

  • According to some advanced scientific studies it has been found that L-carnitine may support brain health and cognitive functions.
  • This is done by improving energy metabolism in the brain and protecting against oxidative stress.
  • It plays a vital role in reducing the risk of cardiovascular diseases and related complications by reducing inflammation, improving cardiac functions, and supporting cardiovascular health.

C. Antioxidant

  • L-carnitine exhibits antioxidant properties, which can safeguard us from oxidative stress that can cause various chronic diseases, such as hypertension and diabetes.
  • Being a good antioxidant, it can combat and flush out the free radicals that are responsible for generating oxidative stress.

2. Health Benefits

L-carnitine can provide several health benefits. Some of them are,

  • Energy production
  • Fat metabolism and managing weight
  • Heart Health
  • Brain Health
  • Muscle function

3. Side Effects

Consumption of L-carnitine is often considered safe for humans with few notable side effects, which are,

  • Gastrointestinal discomfort with symptoms like bloating, nausea, diarrhea, and abdominal cramps.
  • Allergic reactions with symptoms of itching, rashes, and swelling. In the worst-case scenario, breathing problems.
  • Some people may experience an increase in appetite or food cravings.
  • Fish body odor can be experienced when sweat is excreted, and it generally happens with high doses of L-carnitine.

Role of Berberine and L-carnitine in Managing Blood Sugar

Role of Berberine and L-Carnitine in Managing Blood Sugar
Role of Berberine and L-Carnitine in Managing Blood Sugar

Both Berberine and L-Carnitine can have some positive impact on blood sugar. We will see each one’s role one by one.


A. Improving Insulin Sensitivity 

  • It has been found that Berberine can improve insulin sensitivity by helping cells respond effectively to insulin.
  • It can facilitate glucose uptake from the bloodstream to cells.

B. Reducing Glucose Production

  • Berberine can inhibit glucose production in the liver.
  • This will prevent the release of excessive glucose into the bloodstream, thus helping to control high blood sugar.

C. Improving Gut Health

  • Berberine can influence gut microbiota, which plays an important role in glucose metabolism and insulin sensitivity.
  • Improving gut health can indirectly support blood sugar regulation.


A. Glucose Utilization

  • L-carnitine helps to transport fatty acids into mitochondria. There, they will oxidize to release energy.
  • This process helps spare glucose in the body for other essential functions, which can contribute to blood sugar regulation.

B. Reducing Oxidative Stress and Improving Insulin Sensitivity

  • L-carnitine has antioxidant properties that help reduce oxidative stress generated by free radicals. By flushing out free radicals from the body, it can help with diabetes and related complications.
  • According to some studies, L-carnitine showed potential to improve insulin sensitivity which can be beneficial in managing diabetes.

C. Muscle Function

It enhances muscle function and energy production. L-carnitine indirectly supports glucose utilization, helping to manage high blood sugar.

Can I take Berberine and L-carnitine Together?

Can I take Berberine and L-carnitine Together?
Can I take Berberine and L-carnitine Together?

It is not simple to determine whether we should take Berberine and L-carnitine together, as the decision will depend on various factors.

1. Health Factors

  • Health condition (current and historical)
  • Medication regime
  • Individual response

2. Recommendation

It is often recommended that you consult with a healthcare expert before taking both supplements. They will perform a thorough body examination to determine better whether you are a suitable candidate for both.

3. Scientific Recommendation

According to many scientific studies, both Berberine and L-carnitine do not potentially interact with each other. We can take them together (only after consulting with a doctor).

4. Benefits of Berberine and L-carnitine When Taken Together

  • Berberine can protect against high blood sugar by improving insulin sensitivity and regulating glucose metabolism, which can complement L-carnitine’s role in fatty acid transportation and energy production. 
  • Taking both of the supplements together can positively boost metabolism which can control high blood sugar and manage body weight.
  • While we take Berberine, it will improve our heart health. L-carnitine helps produce energy. When combined synergistically, it will improve cardiac health.

Side Effects Combining Both

Side Effects Combining Both
Side Effects Combining Both

Berberine and L-carnitine supplements are both considered safe for human consumption when taken in the recommended dosage. However, before taking them together, we should be aware of some side effects.

1. Digestive Issue

  • If we talk about individual consumption of either of the supplements, they are known for gastrointestinal discomfort.
  • Some symptoms are nausea, bloating, and stomach upset. The side effects are dominant when either taken on an empty stomach or in a high dose.
  • When we combine them, these symptoms can be exacerbated.

2. Allergic Reactions

  • Commonly, individuals are allergic to either or both Berberine and L-carnitine.
  • The allergic reaction has symptoms like itching, rash, or swelling. It can get worse as we begin to feel some respiratory issues.

3. Hypoglycemia

  • Both supplements, Berberine and L-carnitine, can lower blood glucose levels, which can become dangerous in some cases.
  • When hypoglycemia becomes severe, you may not be able to swallow food or beverages safely. By now, blood glucose levels may fall below 40 mg/dl, which can increase the risk of confusion, passing out, or having a seizure.

4. Electrolyte Imbalance

  • When combined, both supplements may cause electrolyte imbalance in some individuals. Individually, they can alter the levels of sodium and potassium in the body.
  • L-carnitine is known to help extract salts like sodium and potassium through urine, which may result in electrolytic imbalance. On the other hand, Berberine is known to influence kidney function and urinary excretion, which may also cause electrolyte imbalance.

5. Interaction

  • Berberine can inhibit the metabolism of certain medications in the liver and increase their levels inside the body.
  • L-carnitine can interact with thyroid-related medicines. Combining them both can worsen the situation.


In conclusion, we want to emphasize on extra caution that we need to take if combining both Berberine and L-carnitine. It is also recommended that we should alter our health supplement consumption under the guidance of a healthcare expert. When taken individually, Berberine can help manage high blood sugar, while L-carnitine helps in energy production, muscle function, and fatty acid metabolism. Additionally, it can also increase the risk of gastrointestinal discomfort, hypoglycemia, allergic reactions, and interaction with other medicines.

Ultimately, both of these health supplements may offer complementary effects, but safety should be the topmost priority. Consulting a healthcare expert before taking any health supplement is a nice way to ensure its long-term health benefits.

Mansi Balodi
Mansi Balodi
My life is always on a run but I try to find time for myself to let my wisdom and knowledge help and guide you. In my blogs, I will try to demystify the complexities of topics and will connect with you with ease of understanding. So let's explore the treasure of the world with words.

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