When to Take Anastrozole with Testosterone: Dosage and Timing


Many consider testosterone one of the most critical hormones for the male body. It’s capable enough to determine some important factors that may define manhood. We can understand its significance by its roles in the male body. It helps maintain muscle mass, bone density, and sex drive. The testosterone levels determine some important aspects. Due to various factors, testosterone levels tend to decline. In that case, doctors suggest testosterone replacement therapy. In this blog, we’ll dig deeper into the topic. The study will tell you “When to Take Anastrozole with Testosterone.” But don’t worry. We’ll break it down for you.

A question must be boggling your mind: what is anastrozole? What is its significance with testosterone?

We’ve talked about testosterone replacement therapy, which is recognized worldwide. But it may come with a price. We may boost testosterone levels with some ill effects. That is when anastrozole, an aromatase inhibitor, comes into play. This medicine aims to lower estrogen levels by blocking an enzyme that converts testosterone to estrogen.

Why can elevated estrogen levels be dangerous? It can give rise to the risk of gynecomastia (man’s breast), mood swings, and water retention. We need to understand how and when to take anastrozole with testosterone. Too large or too little of a dose can create problems, and we must maintain a balance. Timing and dosage play a very crucial role here. I’m sure by the end of this blog, you will feel far more informative. It will help you to make a conscious decision of when and how to take anastrozole with testosterone. It is recommended to consult a healthcare expert for advice.

Testosterone and Impact on the Body with its Depletion

Our bodies secrete testosterone, a hormone. It plays a more vital role in maintaining male health. Testosterone is secreted in the testes in men. In a smaller amount, women’s bodies also release it from ovaries and adrenal glands.

Testosterone and Impact on the Body with its Depletion

1. Key Role in Men’s Health

  • The hormone is crucial, as it’s responsible for developing male reproductive tissues.
  • It can influence behavior, and enhance mood. Testosterone is also responsible for developing secondary sexual traits. These include more muscle and bone.

2. Depletion of Testosterone Levels

  • Testosterone levels start to drop as we move towards the end of adulthood. This happens after age 30.
  • Some individuals might experience a sudden decrease in testosterone levels. Certain symptoms can characterize it. Which are,

3. Symptoms of Decreased Testosterone Levels

Men might experience several symptoms that low testosterone is associated with. It can also be associated with the condition known as hypogonadism.

  • Decrease in muscle mass and body strength.
  • Effect on libido can increase the chances of erectile dysfunction.
  • Constant fatigue and swings in energy levels.
  • Chances of increased body fat.
  • High chances of cognitive issues like memory loss and weaker concentration.
  • The effect on bone density can result in osteoporosis.

Types of Testosterone Therapy

Testosterone replacement therapy (TRT) is the best way to restore healthy testosterone levels. This therapy can improve health and quality of life. Below are some of the preferred methods of TRT.

1. In the form of Topical Gels and Creams

Many products come in topical gels and creams, each of which has its benefits.

Where to Apply

  • These can be applied daily on a clean, dry surface. It can be on the shoulders, abdomen, or upper arms.
  • The cream or gel used in this case is absorbed through the skin. It can take some time to absorb.

Also read: How Long Does Mounjaro Stay in Your System: Understanding the Concept of “Half-Life.”


  • Avoid having skin-to-skin contact for some time. It will allow complete absorption.
Types of Testosterone Therapy


Intramuscular injection can raise testosterone levels.

  • Medicine Used: It’s Enanthate.
  • Duration: Within one to two weeks, and as per prescription.
  • Benefit: Rapid increase in testosterone levels.
  • Drawbacks: It can cause fluctuations in it.

With the help of subcutaneous injections.

  • In this method, we’ve injected testosterone into fatty tissue under the skin.
  • Duration: Weekly, also depending on the prescription.
  • Benefit: Stable and less painful is the intramuscular injection.

2. Oral Medication

  • We can use oral medication to raise testosterone levels. The medication comes in capsules or tablets.
  • The method is less preferred due to the high cost of medicines.
  • Duration: One capsule, twice daily or as prescribed.

3. Buccal Tablets

  • Place the tablets between the gums and the cheek in this method.
  • This method is effective as it bypasses the digestive system and liver.
  • Duration: One tablet, twice daily.

When to Take Anastrozole with Testosterone

Anastrozole is sold under the trade name of Arimidex. It’s an aromatase inhibitor, which helps to cut the side effects of estrogen. Anastrozole is often prescribed together with testosterone therapy. It helps to manage the conversion of testosterone into estrogen.

Before taking the therapy, one should know when to take anastrozole with testosterone. It helps to maximize the effects and neutralize potential side effects.

1. Need to Take it Together

  • Doctors prescribe testosterone therapy for males with low testosterone symptoms. It’s a critical hormone in males that can define sexual health and other various things.
  • While taking the therapy, there can be an increase in estrogen levels. High levels of estrogen in bodies can cause many problems. Gynecomastia and negative effects on libido are major ones.
  • Anastrozole is a medicine that inhibits the enzyme aromatase. It’s responsible for converting testosterone into estrogen.

2. When to Take

  • We should start with a pre-therapy evaluation by a comprehensive body evaluation. We must do a blood test to measure the exact amount of testosterone and estrogen levels.
  • It is recommended to consult a healthcare expert. Discuss your current and historical symptoms.
  • During the therapy, you must do blood tests. Your healthcare provider will guide you through these tests. You’re expected to complete it within 3 to 6 months. We conduct these tests to measure testosterone and estrogen levels.
  • If there is an increased estrogen level, it may sound alarming. At that time, doctors might recommend anastrozole.
  • You must also track the changes. Communicate mood swings, fatigue, and breast tenderness to a healthcare expert.
When to Take Anastrozole with Testosterone

3. Dosage

The dosage of anastrozole is between 0.25 mg to 0.5 mg. It would help if you took it once or twice per week. However, a healthcare expert should determine the exact amount of the medicine. Blood test results should form the basis.

4. Timings

It would help if you took the anastrozole at the same time you take testosterone. It may be shortly after testosterone intake.

Potential Side Effects of Combining Anastrozole with Testosterone.

  • Taking anastrozole with testosterone is a therapeutic approach. It’s generally given during testosterone replacement therapy (TRT) for men.
  • Doctors prescribe Anastrozole to counter elevated estrogen levels. It’s an aromatase inhibitor that minimizes the conversion of testosterone into estrogen.
  • This combination is effective, but we must be aware of side effects. These are:

1. Hormonal Imbalance

Changes in estrogen levels can lead to many behavioral changes. You can experience mood swings, pain in the bones, and an increased risk of fractures.

2. Changes in Lipid

Combining anastrozole with testosterone can increase cholesterol levels. It can increase the risk of cardiovascular diseases.

3. Changes in Sexual Behavior

One can experience a low libido or a desire for sex. It can further cause erectile dysfunction.

4. Risk of Cardiovascular Diseases

The combination can influence lipid profiles and blood clotting. It can further increase changes in cardiovascular disorders.


Doctors can prescribe testosterone replacement therapy (TRT). They prescribe it to those who have low levels of testosterone hormones. The hormone is quite critical for men’s health. It may impact the sexual health of males. TRT given to a patient can influence estrogen levels in the body. It may result in various deformities, with gynecomastia being the major one. You can combine Anastrozole with testosterone to reduce elevated estrogen levels. A question must be boggling your mind: “When to Take Anastrozole with Testosterone?” Regular blood tests may help us determine the changed estrogen levels during TRT. It can help alter the potency of anastrozole given in this specific condition.

Mansi Balodi
Mansi Balodihttps://scriptedsoul.com
My life is always on a run but I try to find time for myself to let my wisdom and knowledge help and guide you. In my blogs, I will try to demystify the complexities of topics and will connect with you with ease of understanding. So let's explore the treasure of the world with words.

Share this article

Recent posts

Popular categories


Please enter your comment!
Please enter your name here

Recent comments